The Red Devils suffered a disappointing 3-0 defeat against Liverpool at Anfield in their latest league fixture, extending their winless streak to two matches.
Similarly, Southampton enter this game following a 3-1 defeat to Brentford. The Saints have yet to secure a point since their return to the Premier League.
WATCH:Southampton vs Manchester United LIVE on Discovery+
The Sporting News looks at the key details ahead of this game, including how to watch the match, kickoff times and the latest lineup news.
Southampton vs. Man United live stream, TV channelHere's how to watch this Premier League match in UK:
TV channel: TNT Sports 1, TNT Sports Ultimate
Live stream: discovery+, discovery+ App
This game is available on TNT Sports 1 and TNT Sports Ultimate for live TV broadcast in UK. Streaming options are available on discovery+ and discovery+ App
STREAM:Biggest Premier League games LIVE on Discovery+
What time does Southampton vs. Man United kick off in UK?This Premier League clash takes place at St. Mary's Stadium in Southampton, United Kingdom and kicks off on Saturday, September 14 at 12:30 p.m. local time.
Southampton vs. Man United lineups, team newsSouthampton lost all three of their opening league games of the season, but there's a strong argument that Russell Martin's side deserved more. They had possessional dominance against Newcastle United, Nottingham Forest and Brentford, only to be undone by a lack of clinical finishing.
That means Martin will probably resist the urge to tinker much with his lineup. Indeed, he could stick with a unchanged side from the 3-1 loss to Brentford, with Aaron Ramsdale in line for a home debut.
Southampton predicted XI (3-5-2, right to left): Ramsdale (GK) — Harwood-Bellis, Bednarek, Stephens — Sugawara, Smallbone, Downes, Aribo, Waker-Peters — Armstrong, Brereton Diaz
Injured: Gavin Bazunu
Suspended:
United captain Bruno Fernandes took a knock to his foot during the international break but insisted it was a minor concern. He will likely start in attack alongside Joshua Zirkzee given Rasmus Hojlund and Mason Mount are sidelined.
Manuel Ugarte will hope to make his debut from the start in midfield, perhaps in place of the under-fire Casemiro, unless Ten Hag decides to give Kobbie Mainoo a break. Amad Diallo should come back into the lineup after being a substitute for the loss to Liverpool.
Man United predicted XI (4-2-2-2, right to left): Onana (GK) — Mazraoui, De Ligt, Martinez, Dalot — Ugarte, Mainoo — Rashford, Amad — Fernandes, Zirkzee
Injured: Leny Yoro, Tyrell Malacia, Mason Mount, Rasmus Hojlund, Victor Lindelof, Luke Shaw, Bruno Fernandes (doubt)
Suspended:
Manchester United enter this match with history on their side. The Red Devils are on a 14-match unbeaten streak against Southampton, last losing to them in 2016.
Both sides have had a far-from-ideal start to their campaigns. The game won't be as clear cut as it has been previously for Manchester United, however, despite their erratic form they should defeat Southampton to get their second win of the season.
Prediction: Southampton 1-3 Manchester UnitedPremier League fixture schedule this weekAll times BST
Saturday, September 14
Southampton vs. Manchester United (12:30 p.m.) Brighton & Hove Albion vs. Ipswich Town (3:00 p.m.) Crystal Palace vs. Leicester City (3:00 p.m.) Fulham vs. West Ham United (3:00 p.m.) Liverpool vs. Nottingham Forest (3:00 p.m.) Manchester City vs. Brentford (3:00 p.m.) Aston Villa vs. Everton (5:30 p.m.)AFC Bournemouth vs. Chelsea (8:00 p.m.)Sunday, September 15
Tottenham Hotspur vs. Arsenal (2:00 p.m.) Wolverhampton Wanderers vs. Newcastle United (4:30 p.m.)