Pep Guardiola's team clinched a 1-0 victory at Wembley with a crucial Aymeric Laporte header, and they will be aiming to repeat this success in their upcoming high-profile showdown next month.
There are just four non-Premier League teams remaining in the competition, with Stoke City, Preston North End, Sheffield Wednesday and possibly AFC Wimbledon representing the lower tiers of English football.
The winner of Wimbledon vs Newcastle, which was rescheduled to October 1 after severe flooding damaged the pitch at Plough Lane saw the game postponed on Tuesday, will host Enzo Maresca's new look Chelsea, while Preston face the daunting task of Arsenal at Deepdale.
Manchester United face another showdown from the top flight, as they welcome Leicester City to Old Trafford.
TrendingElsewhere, Brighton and Hove Albion and Aston Villa both have challenging ties ahead, as they come up against Liverpool and Crystal Palace respectively.
The fixtures will be played in the week commencing October 28 and you can watch every single game live on .
Brentford vs Sheffield Wednesday
Southampton vs Stoke City
Tottenham vs Man City
AFC Wimbledon/Newcastle vs Chelsea
Man United vs Leicester
Brighton vs Liverpool
Preston vs Arsenal
Aston Villa vs Crystal Palace
Quarter-final: w/c December 16
Semi-final: w/c January 6 2025 (first leg) & w/c February 3 2025 (second leg)
Final: Sunday March 16 2025